Characterization of the residual stresses in spray-formed steels using neutron diffraction

Neutron diffraction was used to characterize the residual stresses in an as-sprayed tube-shaped steel preform. The measured residual stress distributions were compared with those simulated using finite element method by taking into account the effects of the thermal history, porosity and different phases of the sprayed preform. The porosity was measured using X-ray microcomputed tomography. The study revealed for the first time the correlation between the distribution of porosity and residual stress developed in the as-sprayed preform

Functional kernel estimators of conditional extreme quantiles

We address the estimation of "extreme" conditional quantiles i.e. when their order converges to one as the sample size increases. Conditions on the rate of convergence of their order to one are provided to obtain asymptotically Gaussian distributed kernel estimators. A Weissman-type estimator and kernel estimators of the conditional tail-index are derived, permitting to estimate extreme conditional quantiles of arbitrary order.Comment: arXiv admin note: text overlap with arXiv:1107.226

Intra-day variability observations and the VLBI structure analysis of quasar S4 0917+624

The IDV observations of S4 0917+624 were carried out monthly, from August 2005 to January 2010, with the Urumqi 25m radio telescope at 4.8 GHz. The quasar S4 0917+624 exhibits only very weak or no IDV during our 4.5 year observing interval. Prior to the year 2000, the source S4 0917+624 was one of the most prominent IDV sources. Our new data indicate that the previous strong IDV has ceased. We analyzed the long-term VLBI structural variability using Gaussian model-fitting. From this we obtained the flux densities and the deconvolved sizes of core and inner-jet components of the source. We studied the properties such as core fraction, angular size, spectral index, and brightness temperature of VLBI core for S4 0917+624, as well as the time delay between 5 and 15 GHz variations, and compared them with the IDV properties of S4 0917+624. The source shows ejection of several jet components that are suspected to have partially reduced the IDV amplitude of S4 0917+624. However, during 2005-2006, the VLBI core size was comparable to the size before the year 2000, but no strong IDV was detected in the period, suggesting that the quenching effect due to source size changes may not be responsible for the lack of strong IDV after the year 2000. The refractive scattering properties for the strong IDV phase of S4 0917+624 before the year 2000 are discussed. The disappearance of strong IDV in S4 0917+624 after the year 2000 is a mystery and cannot be explained via the quenching effect by changes in the observable VLBI structure. However, it may be caused by changes in the interstellar medium, i.e. by interstellar weather, which induces changes in the scintillation pattern on timescales of several years. Further coordinated multi-frequency observations will be required to distinguish between the effect of source-intrinsic variability and changing properties of the interstellar medium.Comment: 8 pages, 6 figures, accepted for publication in A&

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.

DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein degradation, is phosphorylated by DNA-PK and recruited to DNA double-strand break sites to regulate DNA damage repair. However, it is not clear whether VCP is involved in DNA-PKcs (DNA-PK catalytic subunit) degradation or whether it regulates the radiosensitivity of glioblastoma. Our data demonstrated that DNA-PKcs was ubiquitinated and bound to VCP. VCP knockdown resulted in the accumulation of the DNA-PKcs protein in glioblastoma cells, and the proteasome inhibitor MG132 synergised this increase. As expected, this increase promoted the efficiency of DNA repair in several glioblastoma cell lines; in turn, this enhanced activity decreased the radiation sensitivity and prolonged the survival fraction of glioblastoma cells in vitro. Moreover, the VCP knockdown in glioblastoma cells reduced the survival time of the xenografted mice with radiation treatment relative to the control xenografted glioblastoma mice. In addition, the VCP protein was also downregulated in ~25% of GBM tissues from patients (WHO, grade IV astrocytoma), and the VCP protein level was correlated with patient survival (R(2)=0.5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation

Structural Characterization of Rapid Thermal Oxidized Si\u3csub\u3e1−x−y\u3c/sub\u3eGe\u3csub\u3ex\u3c/sub\u3eC\u3csub\u3ey\u3c/sub\u3e Alloy Films Grown by Rapid Thermal Chemical Vapor Deposition

The structural properties of as-grown and rapid thermal oxidized Si1−x−yGexCy epitaxial layers have been examined using a combination of infrared, x-ray photoelectron, x-ray diffraction, secondary ion mass spectroscopy, and Raman spectroscopy techniques. Carbon incorporation into the Si1−x−yGexCy system can lead to compressive or tensile strain in the film. The structural properties of the oxidized Si1−x−yGexCy film depend on the type of strain (i.e., carbon concentration) of the as-prepared film. For compressive or fully compensated films, the oxidation process drastically reduces the carbon content so that the oxidized films closely resemble to Si1−xGex films. For tensile films, two broad regions, one with carbon content higher and the other lower than that required for full strain compensation, coexist in the oxidized films

A fast, high voltage, high frequency modulator at BNL

N/